The crop murbei was known as silkworms food in the activity of nature silk. On the other hand, the leaves murbei also was known was the old ingredients traditional Chinese medicine to treat pengidap the diabetes illness. Various researches about the crop alkaloid murbei that it was suspected was linked was tight to the effect of this medical treatment was carried out, but not any that could explain how the mechanism of these alkaloids could reduce the suffering pengidap was sick this diabetes.
The discovery of the DNJ compound
Actually the DNJ compound was found in the form of synthetic since 1967, but just succeeded in being found in the form of natural him from the leaves extract murbei during 1976 by researchers who came from Japan [1]. Until this the DNJ compound only just succeeded in being isolated from the crop murbei and several strain Bacillus spp then. And more far, this DNJ compound was found to be precise was contained in crop latex murbei, as being sent by the researcher from National Institute of Agrobiological Science-Japan, in one of the sessions of the scientific meeting yearly the 75 Japanese communities of knowledge of nature silk (Japanese Society of Sericultural Science/JSSS) the date 3 and on April 4 2005 that was new then.
The DNJ compound or in his chemical formula C6H13NO4 was the monosaccharide compound that in a manner the structure really resembled glucose and monomer-monomer tetrasakarida in acarbose, only was gotten by few differences in the chain akromatik the DNJ compound was received the cluster of nitrogen (amina). Acarbose personally really has been known as oral medicine non-commercial insulin for the sufferer of the diabetes illness, who was most famous that is having the Glucobay trade in Europe or Precose in the United States trade mark.
Mekanisme kerja DNJ dan acarbose Mekanisme kerja acarbose [2] dalam mengurangi penderitaan pengidap sakit diabetes adalah sebagai berikut : Secara struktur acarbose mirip dengan glukosa, menghambat aktivitas alfa glukosidase, menginterfensi proses hidrolisis karbohidrat, menghambat penyerapan glukosa dan monosakarida-monosakarida yang lainnya
